There are two primary considerations when you are looking at opportunities.  Where is the job and what is the job.  Notice where is the job comes first and what is the job comes second.  But will you be happy living where you want to live if the job is not fulfilling.  You have spent most of your life developing a skill and expertise.  If the job you accept is frustrating & unfulfilling will you truly be happy?  The majority of physicians leave their job because of practice consideration not geographic considerations.  Consider compromising more on the geography to avoid becoming one of the 30%-40% who change jobs in the first 5 years.